Triblock peptide-oligonucleotide chimeras (POCs): programmable biomolecules for the assembly of morphologically tunable and responsive hybrid materialsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc07708d

Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are in...

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Main Authors: Merg, Andrea D, Thaner, Ryan V, Mokashi-Punekar, Soumitra, Nguyen, SonBinh T, Rosi, Nathaniel L
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Summary:Triblock peptide-oligonucleotide chimeras (POCs) consisting of peptides and oligonucleotides interlinked by an organic core are presented and their assembly behaviour is investigated. Several factors influence POC assembly, resulting in the formation of either vesicles or fibres. Design rules are introduced and used to predict and alter POC assembly morphology. Peptide-oligonucleotide chimeras (POCs) assemble into morphologically tunable materials. Design rules for POC assembly are used to predict and alter assembly morphology.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07708d