Discovery of nicoyamycin A, an inhibitor of uropathogenic growth in low iron environments

High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth...

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Published in:Chemical communications (Cambridge, England) England), 2017-11, Vol.53 (95), p.12778-12781
Main Authors: Mike, Laura A, Tripathi, Ashootosh, Blankenship, Connor M, Saluk, Alyssa, Schultz, Pamela J, Tamayo-Castillo, Giselle, Sherman, David H, Mobley, Harry L. T
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Summary:High-throughput screening and activity-guided purification identified nicoyamycin A, a natural product comprised of an uncommon 3-methyl-1,4-dioxane ring incorporated into a desferrioxamine-like backbone via a spiroaminal linkage. Nicoyamycin A potently inhibits uropathogenic Escherichia coli growth in low iron medium, a promising step toward developing novel antibiotics to treat recalcitrant bacterial infections. High-throughput screening and activity-guided purification resulted in the identification of a novel natural product that inhibits uropathogenic Escherichia coli growth.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc07732g