Selective targeting of PARP-1 zinc finger recognition domains with Au(iii) organometallicsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7cc08406d

The binding of Au( iii ) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was expos...

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Bibliographic Details
Main Authors: Wenzel, Margot N, Meier-Menches, Samuel M, Williams, Thomas L, Rämisch, Eberard, Barone, Giampaolo, Casini, Angela
Format: Article
Language:English
Online Access:Get full text
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Summary:The binding of Au( iii ) complexes to the zinc finger domain of the anticancer drug target PARP-1 was studied using a hyphenated mass spectrometry approach combined with quantum mechanics/molecular mechanics (QM/MM) studies. Competition experiments were carried out, whereby each Au complex was exposed to two types of zinc fingers. Notably, the cyclometallated Au-C^N complex was identified as the most selective candidate to disrupt the PARP-1 zinc finger domain, forming distinct adducts compared to the coordination compound Auphen. Insights into gold finger formation by organometallics and implications for targeting pharmacologically relevant zinc-finger proteins.
ISSN:1359-7345
1364-548X
DOI:10.1039/c7cc08406d