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Catalytic carbonyl hydrosilylations via a titanocene borohydride-PMHS reagent systemElectronic supplementary information (ESI) available: Experimental details, IR and NMR spectra. See DOI: 10.1039/c7cy01088e
Reduction of a wide range of aldehydes and ketones with catalytic amounts of titanocene borohydride in concert with a stoichiometric poly(methylhydrosiloxane) (PMHS) reductant is reported. Preliminary mechanistic studies demonstrate that the reaction is mediated by a reactive titanocene( iii ) compl...
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Main Authors: | , , |
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Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | Reduction of a wide range of aldehydes and ketones with catalytic amounts of titanocene borohydride in concert with a stoichiometric poly(methylhydrosiloxane) (PMHS) reductant is reported. Preliminary mechanistic studies demonstrate that the reaction is mediated by a reactive titanocene(
iii
) complex, whose oxidation state remains constant throughout the reaction.
Catalytic amounts of titanocene(
iii
) borohydride, generated under mild conditions from commercially available titanocene dichloride, in concert with a stoichiometric hydride source is shown to effectively reduce aldehydes and ketones to their respective alcohols in aprotic media. |
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ISSN: | 2044-4753 2044-4761 |
DOI: | 10.1039/c7cy01088e |