Unique structural properties of DNA interstrand cross-links formed by a new antitumor dinuclear Pt(ii) complexElectronic supplementary information (ESI) available. See DOI: 10.1039/c7mt00052a

The DNA interstrand cross-links of the antitumor drug {[ cis -Pt(NH 3 ) 2 Cl] 2 (4,4′-methylenedianiline)} 2+ ( 1 ) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′-3′ direction. Conformational distortions induced by these inte...

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Main Authors: Hrabina, O, Kasparkova, J, Suchankova, T, Novohradsky, V, Guo, Z, Brabec, Viktor
Format: Article
Language:English
Online Access:Get full text
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Summary:The DNA interstrand cross-links of the antitumor drug {[ cis -Pt(NH 3 ) 2 Cl] 2 (4,4′-methylenedianiline)} 2+ ( 1 ) play a prevalent role in its antitumor effects. Complex 1 forms DNA long-range interstrand cross-links uniquely in the 3′-3′ direction. Conformational distortions induced by these interstrand cross-links in DNA represent a potential structural motif for recognition by high-mobility-group proteins. Unique long-range DNA interstrand cross-links of a dinuclear platinum complex formed in the 3′-3′ direction affect its antitumor effects.
ISSN:1756-5901
1756-591X
DOI:10.1039/c7mt00052a