Water-mediated and promoted eco-friendly one-pot synthesis of azaarene substituted isoxazolesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7nj01165b

An efficient and green approach for the sp 3 C-H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Nitrostyrylisoxazoles were proven to be good C&z.dbd;C electrophilic acceptors for the construction of various azaarene-containing Mic...

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Main Authors: Nagaraju, Dharavath, Rajanarendar, Eligeti, Praveen Kumar, Pittala, Nagi Reddy, Modugu
Format: Article
Language:English
Online Access:Get full text
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Summary:An efficient and green approach for the sp 3 C-H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described. Nitrostyrylisoxazoles were proven to be good C&z.dbd;C electrophilic acceptors for the construction of various azaarene-containing Michael addition products. This method provides an efficient and environmentally benign method for the one-pot synthesis of biologically important azaarene-substituted isoxazole derivatives in good yields. The important aspects of the present methodology are the use of non-toxic solvent, that it is catalyst free, the ease of purification and the large substrate scope. An efficient and green approach for the sp 3 C-H bond functionalization of 2-methyl azaarenes to 3-methyl-4-nitro-5-styrylisoxazoles in water has been described.
ISSN:1144-0546
1369-9261
DOI:10.1039/c7nj01165b