Lipase catalyzed 1,2-addition of thiols to imines under mild conditionsElectronic supplementary information (ESI) available. See DOI: 10.1039/c7nj03387g

This is the first report of enzymes used as biocatalysts for a 1,2-sulfur addition. In this study, we describe the synthesis of N , S -acetals using an environmentally friendly process with low catalyst loading and in short reaction times using porcine pancreatic lipase, chymosin, and bovine serum a...

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Main Authors: Albuquerque, Tábata B, da Silva, Caren D. G, de Oliveira, Aline R, dos Santos, Beatriz F, da Silva, Beatriz A. L, Katla, Ramesh, Rocha, Mariana P. D, Domingues, Nelson L. C
Format: Article
Language:English
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Summary:This is the first report of enzymes used as biocatalysts for a 1,2-sulfur addition. In this study, we describe the synthesis of N , S -acetals using an environmentally friendly process with low catalyst loading and in short reaction times using porcine pancreatic lipase, chymosin, and bovine serum albumin (BSA). The hydrogen bond between the enzyme and the N -Boc imine is a key factor in this reaction. PPL, chymosin and BSA as efficient biocatalysts (low catalyst loading, high yields) in an eco-friendly synthesis of N , S -acetals.
ISSN:1144-0546
1369-9261
DOI:10.1039/c7nj03387g