Antiproliferative, antioxidant, computational and electrochemical studies of new azo-containing Schiff base ruthenium(ii) complexesElectronic supplementary information (ESI) available. CCDC 1578919-1578921 for compounds 6, 2 and 9, respectively. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7nj04420h

• Main Authors: nan, Ay e, kiz, Mesut, Tayhan, Seçil Erden, Bilgin, Sema, Genç, Nusret, Say n, Koray, Ceyhan, Gökhan, Köse, Muhammet, Da, Ay e, spir, Esin
• Format: Article
• ISSN: 1144-0546; 1369-9261
• DOI: 10.1039/c7nj04420h

A new series of ruthenium( ii ) complexes 7-11 containing the -N&z.dbd;N- group are synthesized and characterized via elemental analysis, and IR, UV-visible and 1 H- 13 C NMR spectroscopy. The solid-state structures of 2 , 6 and 9 are determined by single crystal X-ray diffraction studies. The antiproliferative activities of the Schiff base ligands and their ruthenium( ii ) complexes are investigated in vitro against non-small cell lung cancer cells (H2126), prostate adenocarcinoma cells (PC3) and breast cancer cells (MCF7). The cell proliferation tests are performed as dose-dependent assays at eight concentrations, and 5-fluorouracil is used as the positive control. Compounds 4 and 5 show higher antiproliferative activities against PC3 cells than the other synthesized compounds. Furthermore, the antioxidant capacities of the Schiff base ligands and their ruthenium( ii ) complexes are investigated in vitro via ferric reduction power, DPPH free radical, and ABTS cation radical scavenging activity tests. The radical scavenging activities of complexes 7-11 are found to be higher than BHT, BHA, and Trolox, which are used as positive controls. The antioxidant activity of the complexes is found to be 30-150 fold higher than the ligands. According to obtained results, the ruthenium complexes in this study may be used as antioxidant agents in the food, drug and cosmetic industries. A new series of ruthenium( ii ) complexes 7-11 containing the -N&z.dbd;N- group are synthesized and characterized via elemental analysis, and IR, UV-visible and 1 H- 13 C NMR spectroscopy.