Self-assembly of porphyrin-DNA hybrids into large flat nanostructuresElectronic supplementary information (ESI) available: RP-HPLC chromatograms, UV-Vis spectra of PnC hybrids (n = 1 to 4) and additional AFM images. See DOI: 10.1039/c7ob01267e

• Main Authors: Chatelain, G, Clavé, G, Saint-Pierre, C, Gasparutto, D, Campidelli, S
• Format: Article
• Language: English
• ISSN: 1477-0520; 1477-0539
• DOI: 10.1039/c7ob01267e

The main aim of nanotechnology is to create functional systems by controlling the matter at the nanometer level. In this context DNA is a versatile building block for the fabrication of micrometer-scale objects with a subnanometer-scale resolution. Over the last 15 years, DNA nanotechnology has considerably developed with the invention of DNA origami, double crossover structures and molecule/oligonucleotide hybrids. Our interest is focused on the combination of short complementary DNA sequences with organic molecules with a view to create large self-assembled nanostructures. Here we report on the synthesis of porphyrin derivatives bearing up to four 21-mer oligonucleotides and we demonstrate that the combination of the molecular hybrids containing complementary DNA strands leads to the formation of large nanostructures with micrometer-scale size. Two complementary 21-mer oligonucleotide/porphyrin hybrids were synthesized and assembled into nanostructures.