An innovative small molecule for promoting neuroreparative strategies

In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111 . Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodege...

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Bibliographic Details
Published in:RSC advances 2018-01, Vol.8 (1), p.5451-5458
Main Authors: Colabufo, Nicola Antonio, Contino, Marialessandra, Cantore, Mariangela, Berardi, Francesco, Perrone, Roberto, Tonazzi, Annamaria, Console, Lara, Panaro, Maria Antonietta, Savolainen, Heli, Luurtsema, Gert
Format: Article
Language:English
Subjects:
Chemistry
Differentiation (biology)
Neurodegeneration
Neurological diseases
Signaling
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Summary:In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111 . Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of MC111 , belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by MC111 , open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the in vivo evaluation of MC111 as new tool in neuroreparative medicine. In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111 .
ISSN:2046-2069
2046-2069
DOI:10.1039/c7ra11812k