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An innovative small molecule for promoting neuroreparative strategies
In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule, MC111 . Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodege...
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| Published in: | RSC advances 2018-01, Vol.8 (1), p.5451-5458 |
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| Main Authors: | , , , , , , , , , |
| Format: | Article |
| Language: | English |
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| cited_by | cdi_FETCH-LOGICAL-c454t-b445dd437224afccec17c278d301b9a3495595c4a7161ff67ceb9ac8f246d05c3 |
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| cites | cdi_FETCH-LOGICAL-c454t-b445dd437224afccec17c278d301b9a3495595c4a7161ff67ceb9ac8f246d05c3 |
| container_end_page | 5458 |
| container_issue | 1 |
| container_start_page | 5451 |
| container_title | RSC advances |
| container_volume | 8 |
| creator | Colabufo, Nicola Antonio Contino, Marialessandra Cantore, Mariangela Berardi, Francesco Perrone, Roberto Tonazzi, Annamaria Console, Lara Panaro, Maria Antonietta Savolainen, Heli Luurtsema, Gert |
| description | In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule,
MC111
. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of
MC111
, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by
MC111
, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the
in vivo
evaluation of
MC111
as new tool in neuroreparative medicine.
In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule,
MC111
. |
| doi_str_mv | 10.1039/c7ra11812k |
| format | article |
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MC111
. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of
MC111
, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by
MC111
, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the
in vivo
evaluation of
MC111
as new tool in neuroreparative medicine.
In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule,
MC111
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MC111
. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of
MC111
, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by
MC111
, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the
in vivo
evaluation of
MC111
as new tool in neuroreparative medicine.
In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule,
MC111
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MC111
. Considering the importance of P-gp and BCRP expression on stem cell differentiation and the involvement of TLR4 on neurodegeneration processes, we investigated the effect of
MC111
, belonging to our library of P-gp active compounds on: (i) TLR4 signaling; (ii) P-gp and BCRP activity and expression; (iii) neurite sprouting. The observed findings exerted by
MC111
, open a new scenario for a multitarget and regenerative approach in neurodegenerative diseases encouraging the
in vivo
evaluation of
MC111
as new tool in neuroreparative medicine.
In this study, a new regenerative strategy to treat several neurodegenerative diseases is suggested by the use of a multitarget approach induced by our small molecule,
MC111
.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>35542423</pmid><doi>10.1039/c7ra11812k</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0001-5639-7746</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2046-2069 |
| ispartof | RSC advances, 2018-01, Vol.8 (1), p.5451-5458 |
| issn | 2046-2069 2046-2069 |
| language | eng |
| recordid | cdi_rsc_primary_c7ra11812k |
| source | Open Access: PubMed Central |
| subjects | Chemistry Differentiation (biology) Neurodegeneration Neurological diseases Signaling |
| title | An innovative small molecule for promoting neuroreparative strategies |
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