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Design and 3D printing of a stainless steel reactor for continuous difluoromethylations using fluoroformElectronic supplementary information (ESI) available. See DOI: 10.1039/c7re00176b

Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with n BuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow in...

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Main Authors: Gutmann, Bernhard, Köckinger, Manuel, Glotz, Gabriel, Ciaglia, Tania, Slama, Eyke, Zadravec, Matej, Pfanner, Stefan, Maier, Manuel C, Gruber-Wölfler, Heidrun, Oliver Kappe, C
Format: Article
Language:English
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Summary:Herein we present a continuous flow reactor printed from stainless steel by selective laser melting. The reactor was specifically designed for a fast difluoromethylation reaction with n BuLi as base and fluoroform as atom-economic and inexpensive reagent. The reactor features four inlets to allow introduction of substrate, n BuLi, fluoroform, and a final quench solution. The reaction was completed within less than 2 min at −65 °C. The utilization of stainless steel as reactor material is critical to accomplish the heat transfer as well as the chemical and mechanical resistance that is required for this transformation. The design and 3D printing of a stainless steel reactor for reaction with a gaseous reagent is described.
ISSN:2058-9883
DOI:10.1039/c7re00176b