Phosphine-catalyzed enantioselective [3 + 2] cycloadditions of γ-substituted allenoates with β-perfluoroalkyl enonesElectronic supplementary information (ESI) available: Experimental details, analytical data, NMR spectra of products. CCDC 1503840 (3aa). For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc01432e

The enantioselective construction of densely functionalized cyclopentene bearing contiguous three stereocenters has been a challenging task in organic synthesis. Herein, we present a phoshine-catalyzed highly regio-, diastereo- and enantioselective [3 + 2] cycloaddition of γ-substituted allenoates w...

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Main Authors: Zhou, Wei, Wang, Huamin, Tao, Mengna, Zhu, Chao-Ze, Lin, Tao-Yan, Zhang, Junliang
Format: Article
Language:English
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Summary:The enantioselective construction of densely functionalized cyclopentene bearing contiguous three stereocenters has been a challenging task in organic synthesis. Herein, we present a phoshine-catalyzed highly regio-, diastereo- and enantioselective [3 + 2] cycloaddition of γ-substituted allenoates with β-perfluoroalkyl enones, delivering a wide range of densely functionalized perfluoroalkylated cyclopentenes with three contiguous chiral stereocenters. Herein we present a phoshine-catalyzed highly regio-, diastereo- and enantioselective [3 + 2] cycloaddition of γ-substituted allenoates with β-perfluoroalkyl enones, delivering a wide range of densely functionalized perfluoroalkylated cyclopentenes with three contiguous chiral stereocenters.
ISSN:2041-6520
2041-6539
DOI:10.1039/c7sc01432e