Loading…

A luminescent aluminium salen complex allows for monitoring dynamic vesicle trafficking from the Golgi apparatus to lysosomes in living cells

The Golgi apparatus is well-known as the center of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. The development of fluorescent probes to not only precisely stain the Golgi apparatus but also monitor dynamic vesicle traffi...

Full description

Saved in:
Bibliographic Details
Published in:Chemical science (Cambridge) 2018-02, Vol.9 (7), p.1931-1939
Main Authors: Tang, Juan, Yin, Hao-Yan, Zhang, Jun-Long
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by cdi_FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23
cites cdi_FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23
container_end_page 1939
container_issue 7
container_start_page 1931
container_title Chemical science (Cambridge)
container_volume 9
creator Tang, Juan
Yin, Hao-Yan
Zhang, Jun-Long
description The Golgi apparatus is well-known as the center of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. The development of fluorescent probes to not only precisely stain the Golgi apparatus but also monitor dynamic vesicle trafficking is of great significance. While fluorescent proteins and fluorescent lipid analogs have been reported, they are sometime limited by either overexpression and toxicity or lack of high selectivity, respectively. We herein report a novel approach based on metal-induced coordination between the phosphate anions of phospholipids and the metal center of a luminescent Alsalen complex AlL , which can in situ track membrane vesicle trafficking from the Golgi apparatus to the lysosomes in living cells. This work opens a new avenue for designing luminescent metal probes based on the Lewis acidity of metal ions and allows the use of metal ions with different charge states, polarities, and reactivities within a similar structural scaffold to expand coordination chemistry for biological studies. Tracking vesicle transport from the Golgi apparatus to lysosomes based on an Al 3+ -phospholipid coordination strategy.
doi_str_mv 10.1039/c7sc04498d
format article
fullrecord <record><control><sourceid>proquest_rsc_p</sourceid><recordid>TN_cdi_rsc_primary_c7sc04498d</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2028947633</sourcerecordid><originalsourceid>FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23</originalsourceid><addsrcrecordid>eNpd0U1P3DAQBmCrKgIEXLgXWeJSVVrwRxLbR7SltBISB9pzZJwJNfgjeBLa_RH9z2RZupXqiz2eR6ORXkKOOTvjTJpzp9CxqjK6e0f2Bav4oqmleb99C7ZHjhAf2Hyk5LVQu2RPmEbVQpp98ueChin6BOggjdS-Fn6KFG2ARF2OQ4Df83_Iv5D2udCYkx9z8emedqtko3f0GdC7AHQstu-9e1z3-pIjHX8Cvcrh3lM7DLbYcUI6ZhpWmDFHQOoTDf557R2EgIdkp7cB4ejtPiA_vlx-X35dXN9cfVteXC-cVHJcWKN1L_idqZtKStWYppOONVpwbjirNYOqAyad4Z0AbjSvuaq0slzbWkMn5AH5uJk7lPw0AY5t9LjewCbIE7aCCW0q1Ug509P_6EOeSpq3mxVn2tS6amb1aaNcyYgF-nYoPtqyajlr1zm1S3W7fM3p84xP3kZOdxG6Lf2bygw-bEBBt-3-C1q-ACytmAg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2010895846</pqid></control><display><type>article</type><title>A luminescent aluminium salen complex allows for monitoring dynamic vesicle trafficking from the Golgi apparatus to lysosomes in living cells</title><source>PubMed Central Free</source><creator>Tang, Juan ; Yin, Hao-Yan ; Zhang, Jun-Long</creator><creatorcontrib>Tang, Juan ; Yin, Hao-Yan ; Zhang, Jun-Long</creatorcontrib><description>The Golgi apparatus is well-known as the center of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. The development of fluorescent probes to not only precisely stain the Golgi apparatus but also monitor dynamic vesicle trafficking is of great significance. While fluorescent proteins and fluorescent lipid analogs have been reported, they are sometime limited by either overexpression and toxicity or lack of high selectivity, respectively. We herein report a novel approach based on metal-induced coordination between the phosphate anions of phospholipids and the metal center of a luminescent Alsalen complex AlL , which can in situ track membrane vesicle trafficking from the Golgi apparatus to the lysosomes in living cells. This work opens a new avenue for designing luminescent metal probes based on the Lewis acidity of metal ions and allows the use of metal ions with different charge states, polarities, and reactivities within a similar structural scaffold to expand coordination chemistry for biological studies. Tracking vesicle transport from the Golgi apparatus to lysosomes based on an Al 3+ -phospholipid coordination strategy.</description><identifier>ISSN: 2041-6520</identifier><identifier>EISSN: 2041-6539</identifier><identifier>DOI: 10.1039/c7sc04498d</identifier><identifier>PMID: 29675239</identifier><language>eng</language><publisher>England: Royal Society of Chemistry</publisher><subject>Aluminum ; Cell death ; Cells (biology) ; Fluorescent indicators ; Ions ; Lysosomes ; Metal ions ; Phospholipids ; Proteins ; Toxicity</subject><ispartof>Chemical science (Cambridge), 2018-02, Vol.9 (7), p.1931-1939</ispartof><rights>Copyright Royal Society of Chemistry 2018</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23</citedby><cites>FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23</cites><orcidid>0000-0002-5731-7354</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/29675239$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tang, Juan</creatorcontrib><creatorcontrib>Yin, Hao-Yan</creatorcontrib><creatorcontrib>Zhang, Jun-Long</creatorcontrib><title>A luminescent aluminium salen complex allows for monitoring dynamic vesicle trafficking from the Golgi apparatus to lysosomes in living cells</title><title>Chemical science (Cambridge)</title><addtitle>Chem Sci</addtitle><description>The Golgi apparatus is well-known as the center of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. The development of fluorescent probes to not only precisely stain the Golgi apparatus but also monitor dynamic vesicle trafficking is of great significance. While fluorescent proteins and fluorescent lipid analogs have been reported, they are sometime limited by either overexpression and toxicity or lack of high selectivity, respectively. We herein report a novel approach based on metal-induced coordination between the phosphate anions of phospholipids and the metal center of a luminescent Alsalen complex AlL , which can in situ track membrane vesicle trafficking from the Golgi apparatus to the lysosomes in living cells. This work opens a new avenue for designing luminescent metal probes based on the Lewis acidity of metal ions and allows the use of metal ions with different charge states, polarities, and reactivities within a similar structural scaffold to expand coordination chemistry for biological studies. Tracking vesicle transport from the Golgi apparatus to lysosomes based on an Al 3+ -phospholipid coordination strategy.</description><subject>Aluminum</subject><subject>Cell death</subject><subject>Cells (biology)</subject><subject>Fluorescent indicators</subject><subject>Ions</subject><subject>Lysosomes</subject><subject>Metal ions</subject><subject>Phospholipids</subject><subject>Proteins</subject><subject>Toxicity</subject><issn>2041-6520</issn><issn>2041-6539</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2018</creationdate><recordtype>article</recordtype><recordid>eNpd0U1P3DAQBmCrKgIEXLgXWeJSVVrwRxLbR7SltBISB9pzZJwJNfgjeBLa_RH9z2RZupXqiz2eR6ORXkKOOTvjTJpzp9CxqjK6e0f2Bav4oqmleb99C7ZHjhAf2Hyk5LVQu2RPmEbVQpp98ueChin6BOggjdS-Fn6KFG2ARF2OQ4Df83_Iv5D2udCYkx9z8emedqtko3f0GdC7AHQstu-9e1z3-pIjHX8Cvcrh3lM7DLbYcUI6ZhpWmDFHQOoTDf557R2EgIdkp7cB4ejtPiA_vlx-X35dXN9cfVteXC-cVHJcWKN1L_idqZtKStWYppOONVpwbjirNYOqAyad4Z0AbjSvuaq0slzbWkMn5AH5uJk7lPw0AY5t9LjewCbIE7aCCW0q1Ug509P_6EOeSpq3mxVn2tS6amb1aaNcyYgF-nYoPtqyajlr1zm1S3W7fM3p84xP3kZOdxG6Lf2bygw-bEBBt-3-C1q-ACytmAg</recordid><startdate>20180221</startdate><enddate>20180221</enddate><creator>Tang, Juan</creator><creator>Yin, Hao-Yan</creator><creator>Zhang, Jun-Long</creator><general>Royal Society of Chemistry</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8BQ</scope><scope>8FD</scope><scope>JG9</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-5731-7354</orcidid></search><sort><creationdate>20180221</creationdate><title>A luminescent aluminium salen complex allows for monitoring dynamic vesicle trafficking from the Golgi apparatus to lysosomes in living cells</title><author>Tang, Juan ; Yin, Hao-Yan ; Zhang, Jun-Long</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2018</creationdate><topic>Aluminum</topic><topic>Cell death</topic><topic>Cells (biology)</topic><topic>Fluorescent indicators</topic><topic>Ions</topic><topic>Lysosomes</topic><topic>Metal ions</topic><topic>Phospholipids</topic><topic>Proteins</topic><topic>Toxicity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tang, Juan</creatorcontrib><creatorcontrib>Yin, Hao-Yan</creatorcontrib><creatorcontrib>Zhang, Jun-Long</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>METADEX</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical science (Cambridge)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tang, Juan</au><au>Yin, Hao-Yan</au><au>Zhang, Jun-Long</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A luminescent aluminium salen complex allows for monitoring dynamic vesicle trafficking from the Golgi apparatus to lysosomes in living cells</atitle><jtitle>Chemical science (Cambridge)</jtitle><addtitle>Chem Sci</addtitle><date>2018-02-21</date><risdate>2018</risdate><volume>9</volume><issue>7</issue><spage>1931</spage><epage>1939</epage><pages>1931-1939</pages><issn>2041-6520</issn><eissn>2041-6539</eissn><abstract>The Golgi apparatus is well-known as the center of vesicle trafficking whose malfunction might cause the breakdown of overall cellular architecture and ultimately cell death. The development of fluorescent probes to not only precisely stain the Golgi apparatus but also monitor dynamic vesicle trafficking is of great significance. While fluorescent proteins and fluorescent lipid analogs have been reported, they are sometime limited by either overexpression and toxicity or lack of high selectivity, respectively. We herein report a novel approach based on metal-induced coordination between the phosphate anions of phospholipids and the metal center of a luminescent Alsalen complex AlL , which can in situ track membrane vesicle trafficking from the Golgi apparatus to the lysosomes in living cells. This work opens a new avenue for designing luminescent metal probes based on the Lewis acidity of metal ions and allows the use of metal ions with different charge states, polarities, and reactivities within a similar structural scaffold to expand coordination chemistry for biological studies. Tracking vesicle transport from the Golgi apparatus to lysosomes based on an Al 3+ -phospholipid coordination strategy.</abstract><cop>England</cop><pub>Royal Society of Chemistry</pub><pmid>29675239</pmid><doi>10.1039/c7sc04498d</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0002-5731-7354</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 2041-6520
ispartof Chemical science (Cambridge), 2018-02, Vol.9 (7), p.1931-1939
issn 2041-6520
2041-6539
language eng
recordid cdi_rsc_primary_c7sc04498d
source PubMed Central Free
subjects Aluminum
Cell death
Cells (biology)
Fluorescent indicators
Ions
Lysosomes
Metal ions
Phospholipids
Proteins
Toxicity
title A luminescent aluminium salen complex allows for monitoring dynamic vesicle trafficking from the Golgi apparatus to lysosomes in living cells
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T19%3A35%3A16IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_rsc_p&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=A%20luminescent%20aluminium%20salen%20complex%20allows%20for%20monitoring%20dynamic%20vesicle%20trafficking%20from%20the%20Golgi%20apparatus%20to%20lysosomes%20in%20living%20cells&rft.jtitle=Chemical%20science%20(Cambridge)&rft.au=Tang,%20Juan&rft.date=2018-02-21&rft.volume=9&rft.issue=7&rft.spage=1931&rft.epage=1939&rft.pages=1931-1939&rft.issn=2041-6520&rft.eissn=2041-6539&rft_id=info:doi/10.1039/c7sc04498d&rft_dat=%3Cproquest_rsc_p%3E2028947633%3C/proquest_rsc_p%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c373t-a988f21b9564337696d3c068211910580e4de03c91d2e1981517487a18a58ed23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2010895846&rft_id=info:pmid/29675239&rfr_iscdi=true