Ruthenium-catalyzed hydrogen isotope exchange of C(sp3)-H bonds directed by a sulfur atomElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc00653a

We present here the first example of C(sp 3 )-H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules. We present herein the...

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Main Authors: Gao, Longhui, Perato, Serge, Garcia-Argote, Sébastien, Taglang, Céline, Martínez-Prieto, Luis Miguel, Chollet, Céline, Buisson, David-Alexandre, Dauvois, Vincent, Lesot, Philippe, Chaudret, Bruno, Rousseau, Bernard, Feuillastre, Sophie, Pieters, Grégory
Format: Article
Language:English
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Summary:We present here the first example of C(sp 3 )-H activation directed by a sulfur atom. Based on this transformation catalyzed by Ru/C, we have developed a hydrogen isotope exchange reaction for the deuterium and tritium labelling of thioether substructures in complex molecules. We present herein the first general method for deuterium and tritium labelling of thioether substructures in complex molecules.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc00653a