High-yielding F radiosynthesis of a novel oxytocin receptor tracer, a probe for nose-to-brain oxytocin uptake

A novel Al 18 F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake follow...

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Published in:Chemical communications (Cambridge, England) England), 2018-07, Vol.54 (58), p.812-8123
Main Authors: Beard, Rhiannon, Singh, Nisha, Grundschober, Christophe, Gee, Antony D, Tate, Edward W
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Summary:A novel Al 18 F labelled peptide tracer for PET imaging of oxytocin receptor has been accessed through a high radiochemical yield approach. This tracer showed comparable affinity and higher selectivity and stability compared to oxytocin, and was used to demonstrate direct nose-to-brain uptake following intranasal administration, a common yet controversial delivery route for oxytocin-based therapeutics. Probing the mechanism of intranasal oxytocin brain uptake through generation and validation of a novel peptide PET tracer.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01400k