Synthesis of spiroindolenines by intramolecular ipso-iodocyclization of indol ynonesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8cc01474d

A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N -iodosuccinimide. The formation of the desired product occurs in an atom-economical way, under mild conditions, instantly after the addition of the reagent. The expected 1,2-rearrangement was not...

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Main Authors: Fedoseev, Pavel, Coppola, Guglielmo, Ojeda, Gerardo M, Van der Eycken, Erik V
Format: Article
Language:English
Online Access:Get full text
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Summary:A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N -iodosuccinimide. The formation of the desired product occurs in an atom-economical way, under mild conditions, instantly after the addition of the reagent. The expected 1,2-rearrangement was not observed. The procedure represents a metal free spirocyclization of indoles with an opportunity for further functionalizations. A high-yielding fast spirocyclization of easily available indol ynones has been developed by applying N -iodosuccinimide.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc01474d