Polyethyleneimine methylenecarboxylate: a macromolecular DTPA analogue to chelate plutonium(iv)Electronic supplementary information (ESI) available. See DOI: 10.1039/c8cc05206a

Up until now, molecular chelating agents, such as diethylenetriamine pentaacetic acid (DTPA), have been the standard method for actinide human decorporation. Mainly active in blood serum, their distribution within the body is thus limited. To treat a wider range of organs affected by plutonium conta...

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Bibliographic Details
Main Authors: Lahrouch, Florian, Siberchicot, Bruno, Leost, Laurane, Aupiais, Jean, Rossberg, André, Hennig, Christoph, Den Auwer, Christophe, Di Giorgio, Christophe
Format: Article
Language:English
Online Access:Get full text
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Summary:Up until now, molecular chelating agents, such as diethylenetriamine pentaacetic acid (DTPA), have been the standard method for actinide human decorporation. Mainly active in blood serum, their distribution within the body is thus limited. To treat a wider range of organs affected by plutonium contamination, a potential new class of macromolecular decorporation agents is being studied. Polyethyleneimine methylenecarboxylate (PEI-MC) is one such example. It is being considered here because of its capacity for targeting the liver and bones. Polyethyleneimine methylenecarboxylate (PEI-MC) is explored as a possible new class of macromolecular decorporation agents in case of plutonium contamination.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05206a