Stereoselective aldol reactions using pseudo symmetric 1-benzyl-4-(trifluoromethyl)piperidine-2,6-dione

Crossed aldol reactions of the CF 3 -containing pseudo C 2 symmetric cyclic imide 3 were carried out by way of the corresponding boron bisenolate to stereoselectively furnish the desired products 4 and this procedure allowed the preferential construction of the diastereomers of the compounds previou...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-08, Vol.54 (71), p.9913-9916
Main Authors: Inoue, Yuta, Hatayama, Takahiro, Kawasaki-Takasuka, Tomoko, Agou, Tomohiro, Kubota, Toshio, Yamazaki, Takashi
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Summary:Crossed aldol reactions of the CF 3 -containing pseudo C 2 symmetric cyclic imide 3 were carried out by way of the corresponding boron bisenolate to stereoselectively furnish the desired products 4 and this procedure allowed the preferential construction of the diastereomers of the compounds previously obtained from the acyclic counterpart 1 . Crossed aldol reactions of the CF 3 -containing pseudo C 2 symmetric cyclic imide 3 were performed by way of the corresponding lithium and boron bisenolates to stereoselectively furnish the desired products 4 .
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc05458d