High thermal stability, pH responsive organogels of 2H-benzo[d]1,2,3-triazole derivatives as pharmaceutical crystallization mediaElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ce01742e

2 H -Benzo[ d ]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the p...

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Bibliographic Details
Main Authors: Torres-Moya, Iván, Saikia, Basanta, Prieto, Pilar, Carrillo, José R, Steed, Jonathan W
Format: Article
Language:English
Online Access:Get full text
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Summary:2 H -Benzo[ d ]1,2,3-triazole derivatives with a range of chemical functionalities showed significant organogel formation, particularly bis-amide derivative 4e which gave robust thermally stable gels, in a range of solvents down to 0.1 wt%. The gelators proved responsive under pH stimuli or to the presence of metal cations. The gels also proved to be useful vehicles to crystallize pharmaceutical drugs, resulting in a change in polymorphic outcome in the case of sulfathiazole compared to the solution crystallization outcome. 2 H -Benzo[ d ]1,2,3-triazole derivatives give rise to a supergelator that results in the crystallization of kinetic form I sulfathiazole.
ISSN:1466-8033
DOI:10.1039/c8ce01742e