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polysaccharides extend the mean lifespan of
The fruits of Lycium barbarum are considered medicinal foods with high nutritional value and bioactivity. In this study, we aimed to evaluate the effect of a crude L. barbarum polysaccharide (LBP) and two derived fractions, LBP-1 and LBP-2, on the lifespan of Drosophila melanogaster (fruit fly). The...
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Published in: | Food & function 2019-07, Vol.1 (7), p.4231-4241 |
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Main Authors: | , , , , , , , , , , |
Format: | Article |
Language: | |
Online Access: | Get full text |
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Summary: | The fruits of
Lycium barbarum
are considered medicinal foods with high nutritional value and bioactivity. In this study, we aimed to evaluate the effect of a crude
L. barbarum
polysaccharide (LBP) and two derived fractions, LBP-1 and LBP-2, on the lifespan of
Drosophila melanogaster
(fruit fly). The average lifespan of fruit flies was extended by supplementing their diet with either of the three LBP preparations.
In vivo
analysis of antioxidant activities detected increased superoxide dismutase (SOD) and catalase (CAT) activities and decreased malondialdehyde (MDA) levels. Dietary LBP supplements significantly reduced the mortality rate of fruit flies induced by paraquat and hydrogen peroxide. Importantly, the strongest anti-aging activity was exhibited by the LBP-2 fraction, containing arabinogalactan with a molecular weight of 9 Ă— 10
4
Da. Further studies showed that the anti-aging activity of LBP was, at least in part, mediated by an age-related signaling pathway (
MAPK
,
TOR
,
S6K
) and the expression of longevity genes (
Hep
,
MTH
, and
Rpn11
).
The fruits of
Lycium barbarum
are considered medicinal foods with high nutritional value and bioactivity. |
---|---|
ISSN: | 2042-6496 2042-650X |
DOI: | 10.1039/c8fo01751d |