A tailored polymeric cationic tag-anionic Pd(ii) complex as a catalyst for the low-leaching Heck-Mizoroki coupling in flow and in biomass-derived GVLElectronic supplementary information (ESI) available: Experimental section and representative E-factor calculation, full characterization of compounds and copies of the 1H and 13C NMR spectra. See DOI: 10.1039/c8gc03228a

• Main Authors: Mahmoudi, Hamed, Valentini, Federica, Ferlin, Francesco, Bivona, Lucia Anna, Anastasiou, Ioannis, Fusaro, Luca, Aprile, Carmela, Marrocchi, Assunta, Vaccaro, Luigi
• Format: Article
• Language: English
• ISSN: 1463-9262; 1463-9270
• DOI: 10.1039/c8gc03228a

The [PdCl 4 ] 2− palladium complex has been immobilized on a polystyrene-type resin loaded with pincer-type imidazolium ionic tag binding sites. The catalytic system (Pd( ii )-POLI-TAG) has proved to be highly active in the definition of an efficient protocol for the Heck-Mizoroki coupling reaction under batch and flow conditions. Importantly, it is shown to be highly robust in combination with a safe non-toxic reaction medium, i.e. biomass-derived GVL, since it could be reused for multiple runs without significantly losing its activity. A new polystyrene-type resin loaded with pincer-type imidazolium ionic tag has been very effective in the immobilization of [PdCl 4 ] 2− palladium complex leading to a very low leaching of the metal during its use in flow.