A one-pot catalyst/external oxidant/solvent-free cascade approach to pyrimidines a 1,5-hydride transfer

A cascade 3-component reaction of 6-aminouracil, aldehyde and tetrahydroisoquinolines under heating in the absence of catalyst, external oxidant and solvent is performed. The reaction constructs a new pyrimidine ring by the functionalization of the C-H bond adjacent to nitrogen through a 1,5-hydride...

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Published in:Green chemistry : an international journal and green chemistry resource : GC 2019-01, Vol.21 (1), p.69-74
Main Authors: Deb, Mohit L, Borpatra, Paran J, Baruah, Pranjal K
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Summary:A cascade 3-component reaction of 6-aminouracil, aldehyde and tetrahydroisoquinolines under heating in the absence of catalyst, external oxidant and solvent is performed. The reaction constructs a new pyrimidine ring by the functionalization of the C-H bond adjacent to nitrogen through a 1,5-hydride shift. No chromatographic techniques were required to purify the products. A cascade reaction for synthesizing pyrimidines by the functionalization of the C-H bond adjacent to nitrogen through a 1,5-hydride shift is reported.
ISSN:1463-9262
1463-9270
DOI:10.1039/c8gc03507e