Synthesis of a class of binaphthyl monophosphine ligands with a naphthofuran skeleton and their applications in Suzuki-Miyaura coupling reactionsElectronic supplementary information (ESI) available. See DOI: 10.1039/c8nj00412a

A series of new monophosphine ligands containing a naphthofuran skeleton have been prepared, characterized and evaluated in palladium-catalyzed Suzuki-Miyaura coupling reactions. Using Pd 2 (dba) 3 - L6 as the catalyst the reactions were performed with high catalytic activity under mild reaction con...

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Main Authors: Zhou, Zihong, Liang, Hao, Xia, Wang, Chen, Huixuan, Zhang, Yaqi, He, Xuefeng, Yu, Sifan, Cao, Rihui, Qiu, Liqin
Format: Article
Language:English
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Summary:A series of new monophosphine ligands containing a naphthofuran skeleton have been prepared, characterized and evaluated in palladium-catalyzed Suzuki-Miyaura coupling reactions. Using Pd 2 (dba) 3 - L6 as the catalyst the reactions were performed with high catalytic activity under mild reaction conditions and the desired coupling products were obtained in good to excellent yields. The new catalyst system also showed broad substrate adaptability and practicality for gram-scale production. L6 -Pd 2 (dba) 3 showed excellent activity in the Suzuki-Miyaura reaction of sterically hindered and electron-rich aryl halides with aryl boronic acids.
ISSN:1144-0546
1369-9261
DOI:10.1039/c8nj00412a