Challenges in the configuration assignment of natural products. A case-selective perspectiveThis paper is dedicated to the memory of Prof. Ernesto Fattorusso (1937-2012)

Covering: up to 2018 Even today, when planar structures of natural products can be determined with microgram samples, the configurational assignment continues to be a challenge. The relative and absolute configurations of natural products can be assigned by devising original approaches, relying on c...

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Bibliographic Details
Main Authors: Menna, Marialuisa, Imperatore, Concetta, Mangoni, Alfonso, Della Sala, Gerardo, Taglialatela-Scafati, Orazio
Format: Article
Language:English
Online Access:Get full text
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Summary:Covering: up to 2018 Even today, when planar structures of natural products can be determined with microgram samples, the configurational assignment continues to be a challenge. The relative and absolute configurations of natural products can be assigned by devising original approaches, relying on carefully acquired data on a case-by-case basis. In this review, the most widely available methods and techniques for the absolute configuration determination of novel natural products are concisely discussed. Selected illustrative examples (case studies) are presented, where original approaches integrating different chemical, spectroscopic, and/or computational methods have been devised to solve intriguing stereochemistry issues of natural small molecules. An overview by a case study approach on the currently available methods for the configurational analysis of natural products.
ISSN:0265-0568
1460-4752
DOI:10.1039/c8np00053k