Responsive upconversion nanoprobe for monitoring and inhibition of EBV-associated cancers via targeting EBNA1Electronic supplementary information (ESI) available. See DOI: 10.1039/c8nr05015e

Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF 4 :Yb 3+ ,Er 3+ @NaGdF 4 (UCNP) with peptides to achieve responsive UC emission...

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Main Authors: Zha, Shuai, Fung, Yan Ho, Chau, Ho-Fai, Ma, Ping'an, Lin, Jun, Wang, Jing, Chan, Lai Sheung, Zhu, Guang, Lung, Hong Lok, Wong, Ka-Leung
Format: Article
Language:English
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Summary:Non-responsive emission enhancement is the disadvantage of upconversion nanomaterials (UCNM) when compared with conventional organic based agents for molecular imaging. We herein show a new strategy by conjugating NaGdF 4 :Yb 3+ ,Er 3+ @NaGdF 4 (UCNP) with peptides to achieve responsive UC emission enhancement upon binding to a targeted protein - EBNA1. EBNA1 is a well-known viral latent protein for the EBV-associated cancer. Peptide-coating of the functionalized core-shell nanoparticle diminishes upconverted emission intensity drastically. However, the peptide-coated UCNP shows selective and responsive UC emission enhancement via aggregation with the targeted protein. This phenomenon paves a new way for UCNM in molecular imaging. Responsive emission enhancement was observed between EBNA1 and dual-function EBNA1-targeting nanoprobe UCNP-P 4 , monitoring and inhibition of EBV-associated tumor is achieved.
ISSN:2040-3364
2040-3372
DOI:10.1039/c8nr05015e