A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximesElectronic supplementary information (ESI) available: Experimental procedures and characterization data of products. See DOI: 10.1039/c8ob01064a

A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed. CuBr 2 exhibited higher activity than other copper salts, affording the desired furocoumarins in high yields. The transformation proceeded readily in the absence of stoic...

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Main Authors: To, Tuong A, Vo, Yen H, Nguyen, Anh T, Phan, Anh N. Q, Truong, Thanh, Phan, Nam T. S
Format: Article
Language:English
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Summary:A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed. CuBr 2 exhibited higher activity than other copper salts, affording the desired furocoumarins in high yields. The transformation proceeded readily in the absence of stoichiometric external oxidants. The significance of this synthetic strategy would be (1) the easily available starting materials; (2) low cost catalyst CuBr 2 ; and (3) being without stoichiometric external oxidants. This protocol is complementary to previous approaches in the synthesis of substituted furocoumarins. A new route to substituted furocoumarins via copper-catalyzed cyclization between 4-hydroxycoumarins and ketoximes was developed.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob01064a