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Xylopsides A-D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from

Four unprecedented guaiane dimers, xylopsides A-D ( 1-4 ), were isolated and identified from the roots of Xylopia vielana. The structures of 1-4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1-4 showed two bridged pentacyclic skeletons between two guaiane-typ...

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Published in:Organic & biomolecular chemistry 2018-09, Vol.16 (37), p.848-8412
Main Authors: Xie, Yang-Guo, Guo, Yi-Gong, Wu, Guo-Jing, Zhu, Sheng-Lan, Cheng, Tao-Fang, Zhang, Yu, Yan, Shi-Kai, Jin, Hui-Zi, Zhang, Wei-Dong
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Summary:Four unprecedented guaiane dimers, xylopsides A-D ( 1-4 ), were isolated and identified from the roots of Xylopia vielana. The structures of 1-4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1-4 showed two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds, 4 exhibited a moderate inhibitory activity against the production of nitric oxide with an IC 50 value of 25.7 μM in RAW264.7 cells stimulated by LPS. Four compounds with two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob01689e