Loading…
Xylopsides A-D, four rare guaiane dimers with two unique bridged pentacyclic skeletons from
Four unprecedented guaiane dimers, xylopsides A-D ( 1-4 ), were isolated and identified from the roots of Xylopia vielana. The structures of 1-4 were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra. 1-4 showed two bridged pentacyclic skeletons between two guaiane-typ...
Saved in:
Published in: | Organic & biomolecular chemistry 2018-09, Vol.16 (37), p.848-8412 |
---|---|
Main Authors: | , , , , , , , , |
Format: | Article |
Language: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Summary: | Four unprecedented guaiane dimers, xylopsides A-D (
1-4
), were isolated and identified from the roots of
Xylopia vielana.
The structures of
1-4
were elucidated by spectroscopic analysis, Cu Kα X-ray crystallography and CD spectra.
1-4
showed two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. Among these compounds,
4
exhibited a moderate inhibitory activity against the production of nitric oxide with an IC
50
value of 25.7 μM in RAW264.7 cells stimulated by LPS.
Four compounds with two bridged pentacyclic skeletons between two guaiane-type sesquiterpenes, which were characterized as two different bridged ring systems. |
---|---|
ISSN: | 1477-0520 1477-0539 |
DOI: | 10.1039/c8ob01689e |