TBAI-catalyzed selective synthesis of sulfonamides and β-aryl sulfonyl enamines: coupling of arenesulfonyl chlorides and sodium sulfinates with tert-aminesElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob02992j

A simple, practical and metal-free method has been developed for the synthesis of sulfonamides and β-arylsulfonyl enamines via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides and sodium sulfinates with tert -amines. The method uses commer...

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Main Authors: Jiang, Hongmei, Tang, Xiaoyue, Xu, Zhihui, Wang, Huixian, Han, Kang, Yang, Xiaolan, Zhou, Yuanyuan, Feng, Yong-Lai, Yu, Xian-Yong, Gui, Qingwen
Format: Article
Language:English
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Summary:A simple, practical and metal-free method has been developed for the synthesis of sulfonamides and β-arylsulfonyl enamines via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides and sodium sulfinates with tert -amines. The method uses commercially available inexpensive catalysts and oxidants, and has a wide substrate scope and operational simplicity. A simple, practical and metal-free method for the synthesis of title compounds via the selective cleavage of C-N and C-H bonds through the iodine-catalyzed oxidation of arenesulfonyl chlorides and sodium sulfinates with tert -amines.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob02992j