A mitochondria-targeted red-emitting probe for imaging hydrogen sulfide in living cells and zebrafishElectronic supplementary information (ESI) available. See DOI: 10.1039/c8ob03219j

Hydrogen sulfide (H 2 S) is an important endogenous signaling molecule with multiple biological functions. Based on the thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) amine, herein we rationally design and synthesize a new fluorescent probe 1 for the detection of mitochondrial H 2 S in living cells...

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Bibliographic Details
Main Authors: Ismail, Ismail, Wang, Dan, Wang, Dawei, Niu, Cuili, Huang, Haojie, Yi, Long, Xi, Zhen
Format: Article
Language:English
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Summary:Hydrogen sulfide (H 2 S) is an important endogenous signaling molecule with multiple biological functions. Based on the thiolysis of NBD (7-nitro-1,2,3-benzoxadiazole) amine, herein we rationally design and synthesize a new fluorescent probe 1 for the detection of mitochondrial H 2 S in living cells. Probe 1 displays bright red-emitting fluorescence after H 2 S activation ( , 0.77). 1 shows higher selectivity and sensitivity for H 2 S than the red-emitting probe Rho-NBD ( ChemBioChem , 2016, 17 , 962). Moreover, 1 is water-soluble, cell-membrane-permeable, of low cytotoxicity and mitochondria-targeting, and can be employed for monitoring mitochondrial H 2 S in living cells. A mitochondria-targeted red-emitting probe is designed and prepared for H 2 S detection in living cells and zebrafish.
ISSN:1477-0520
1477-0539
DOI:10.1039/c8ob03219j