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The anti-diarrhea activity of red algae-originated sulphated polysaccharides on ETEC-K88 infected mice
Polysaccharides from red algae Porphyra haitanensis and Gracilaria lemaneiformis possess various bioactive functions, however, their anti-diarrhea activity remains incompletely defined. In the current study, sulphated polysaccharides were extracted by high pressure treatment plus ethanol precipitati...
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Published in: | RSC advances 2019-01, Vol.9 (5), p.236-237 |
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Main Authors: | , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Polysaccharides from red algae
Porphyra haitanensis
and
Gracilaria lemaneiformis
possess various bioactive functions, however, their anti-diarrhea activity remains incompletely defined. In the current study, sulphated polysaccharides were extracted by high pressure treatment plus ethanol precipitation from these two algae, and named PHSP
(hp)
and GLSP
(hp)
, respectively. PHSP
(hp)
and GLSP
(hp)
showed decreased viscosity and molecular weight. Meanwhile, they have a certain immunomodulatory effect on wound healing and migration of RAW264.7 cells. Moreover, they significantly increased the secretion of pro-inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). A BALB/c model infected by enterotoxigenic
Escherichia coli
(ETEC)-K88 was also established to evaluate the anti-diarrhea activity of PHSP
(hp)
and GLSP
(hp)
. The results showed that PHSP
(hp)
and GLSP
(hp)
were able to alleviate mice diarrhea symptoms. Meanwhile, they inhibited the release of pro-inflammatory cytokines and suppressed the secretion of immunoglobulin A
via
reducing the population of B cells. In addition, the nitroblue tetrazolium levels of mouse serum were decreased. Taken together, PHSP
(hp)
and GLSP
(hp)
alleviated the inflammatory response of ETEC-K88-induced diarrhea through both specific and non-specific immunity. Sulphated polysaccharides from red algae may be used as functional food components for remitting diarrhea.
Polysaccharides from red algae
Porphyra haitanensis
and
Gracilaria lemaneiformis
possess various bioactive functions, however, their anti-diarrhea activity remains incompletely defined. |
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ISSN: | 2046-2069 2046-2069 |
DOI: | 10.1039/c8ra09247h |