Linker chemistry dictates the delivery of a phototoxic organometallic rhenium() complex to human cervical cancer cells from core crosslinked star polymer nanoparticles

We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re( i ) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-li...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2018-12, Vol.6 (47), p.785-781
Main Authors: Yu, Sul Hwa, Patra, Malay, Ferrari, Stefano, Ramirez Garcia, Paulina, Veldhuis, Nicholas A, Kaminskas, Lisa M, Graham, Bim, Quinn, John F, Whittaker, Michael R, Gasser, Gilles, Davis, Thomas P
Format: Article
Language:English
Subjects:
Acrylamide
Benzaldehyde
Biodegradability
Biodegradation
Cancer
Cervical cancer
Cervix
Chemical Sciences
Crosslinking
Cytotoxicity
Ethylene glycol
Lungs
Medicinal Chemistry
Nanoparticles
Organic chemistry
Polyethylene glycol
Rhenium
Toxicity testing
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Summary:We have investigated core-crosslinked star polymer nanoparticles designed with tunable release chemistries as potential nanocarriers for a photoactive Re( i ) organometallic complex. The nanoparticles consisted of a brush poly(oligo-ethylene glycol)methyl ether acrylate (POEGA) corona and a cross-linked core of non-biodegradable N , N ′-methylenebis(acrylamide) (MBAA) and either pentafluorophenyl acrylate (PFPA), 3-vinyl benzaldehyde (VBA) or diacetone acrylamide (DAAM). Each star was modified with an amine functionalized photodynamic agent ( i.e. a rhenium( i ) organometallic complex) resulting in the formation of either a stable amide bond (POEGA- star -PFPA), or hydrolytically labile aldimine (POEGA- star -VBA) or ketimine bonds (POEGA- star -DAAM). These materials revealed linker dependent photo- and cytotoxicity when tested in vitro against non-cancerous lung fibroblast MRC-5 cells and HeLa human cervical cancer cells: the toxicity results correlated with final intracellular Re concentrations. Release of a photoactive Re( i ) complex from a polymer star via ketimine linkages gives improved phototoxicity.
ISSN:2050-750X
2050-7518
DOI:10.1039/c8tb02464b