Target-assisted self-cleavage DNAzyme probes for multicolor simultaneous imaging of tumor-related microRNAs with signal amplificationElectronic supplementary information (ESI) available: Experimental details and additional figures. See DOI: 10.1039/c9cc00451c

In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also...

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Main Authors: Wan, Yuan-Hui, Zhou, Yu-Jie, Xiao, Ke-Jing, Nie, Cun-Peng, Zhang, Juan, Liu, Chang, Chen, Ting-Ting, Chu, Xia
Format: Article
Language:English
Online Access:Get full text
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Summary:In this work, we have developed a novel and highly selective signal amplification strategy based on target-assisted self-cleavage DNAzyme probes for multicolor and simultaneous imaging of miRNA-222 and miRNA-223 in living cells. The fluctuation of miRNA-222 and miRNA-223 expression levels could also be monitored. A novel and highly selective signal amplification strategy was developed based on target-assisted self-cleavage DNAzyme probes for imaging of miRNA-222 and miRNA-223.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc00451c