Second generation DNA-encoded dynamic combinatorial chemical librariesElectronic supplementary information (ESI) available. See DOI: 10.1039/c9cc01429b

We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to st...

Full description

Saved in:
Bibliographic Details
Main Authors: Reddavide, Francesco V, Cui, Meiying, Lin, Weilin, Fu, Naiqiang, Heiden, Stephan, Andrade, Helena, Thompson, Michael, Zhang, Yixin
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We present a DNA-encoded chemical library, which allows dynamic selection followed by ligation of the encoding strands. As a chemical approach to mimic the genetic recombination process of adaptive immunity, the technology led to an enhanced enrichment factor and signal-to-noise ratio compared to static libraries. A novel DNA-encoded chemical library architecture can mimic the mechanisms of immunity to evolve binders through recombination, dynamics and adaption.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc01429b