Enhanced visualization of cell surface glycans a hybridization chain reaction

Herein, we apply a DNA hybridization chain reaction (HCR) to achieve sensitively amplified imaging of cell surface glycosylation with reduced non-natural monosaccharide units. This method is simple, efficient, sensitive, and possesses great potential to illuminate the pathways via which cell surface...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-05, Vol.55 (43), p.6114-6117
Main Authors: Wen, Xiaohong, Yuan, Baoyin, Zhang, Junxun, Meng, Xiangxian, Guo, Qiuping, Li, Lie, Li, Zenghui, Jiang, Huishan, Wang, Kemin
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Summary:Herein, we apply a DNA hybridization chain reaction (HCR) to achieve sensitively amplified imaging of cell surface glycosylation with reduced non-natural monosaccharide units. This method is simple, efficient, sensitive, and possesses great potential to illuminate the pathways via which cell surface glycosylation regulates cell functions. We apply a DNA hybridization chain reaction (HCR) to achieve sensitively amplified imaging of cell surface glycosylation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc02069a