Trehalose-based Siamese twin amphiphiles with tunable self-assembling, DNA nanocomplexing and gene delivery properties

An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasm...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-07, Vol.55 (57), p.8227-823
Main Authors: Carbajo-Gordillo, Ana I, Rodríguez-Lavado, Julio, Jiménez Blanco, José Luis, Benito, Juan M, Di Giorgio, Christophe, Vélaz, Itziar, Tros de Ilarduya, Concepción, Ortiz Mellet, Carmen, García Fernández, José M
Format: Article
Language:English
Subjects:
Animals
Cell Line
Cercopithecus aethiops
Disaccharides
Humans
Mice
Nanoparticles
Nanostructures - chemistry
NMR
Nuclear magnetic resonance
Plasmids
Plasmids - chemistry
Plasmids - metabolism
Surface-Active Agents - chemistry
Topology
Transfection - methods
Trehalose
Trehalose - chemistry
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Summary:An original family of multivalent vectors encompassing gemini and facial amphiphilicity, namely cationic Siamese twin surfactants, has been prepared from the disaccharide trehalose; molecular engineering lets us modulate the self-assembling properties and the topology of the nanocomplexes with plasmid DNA for efficient gene delivery in vitro and in vivo . Trehalose Siamese twin vectors, encompassing gemini and facial amphiphilicity, promote pDNA compaction into core-shell nanocomplexes and selective delivery in the lungs.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc04489b