Drug orientations within statin-loaded lipoprotein nanoparticles by F solid-state NMR

NMR measurements of 19 F chemical shift anisotropy and 1 H- 19 F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug deliv...

Full description

Saved in:
Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (88), p.13287-1329
Main Authors: Lau, Sophie, Stanhope, Naomi, Griffin, John, Hughes, Eleri, Middleton, David A
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:NMR measurements of 19 F chemical shift anisotropy and 1 H- 19 F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation. NMR measurements of 19 F chemical shift anisotropy and 1 H- 19 F dipolar couplings provide novel information on the molecular orientation of fluorine-containing statin drugs in rHDL lipoprotein nanoparticles, a drug delivery system under investigation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc05344a