Enantioselective arylaryl coupling facilitated by chiral binuclear gold complexes

Herein, we report stoichiometric investigations embodying the first highly enantioselective arylaryl coupling facilitated by a gold complex. With up to 91% ee, this is the first demonstration of a transmetalation and C(sp 2 )C(sp 2 ) reductive elimination sequence with high enantioselectivity using...

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Published in:Chemical communications (Cambridge, England) England), 2019-10, Vol.55 (86), p.12988-12991
Main Authors: Himmelstrup, Jonas, Buendia, Mikkel B, Sun, Xing-Wen, Kramer, Sren
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Summary:Herein, we report stoichiometric investigations embodying the first highly enantioselective arylaryl coupling facilitated by a gold complex. With up to 91% ee, this is the first demonstration of a transmetalation and C(sp 2 )C(sp 2 ) reductive elimination sequence with high enantioselectivity using a gold complex. The results offer a basis for development of enantioselective gold-catalyzed arylaryl coupling reactions. The first example of highly enantioselective arylaryl coupling mediated by chiral gold complexes is reported.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc07175j