pH stimulus-disaggregated BODIPY: an activated photodynamic/photothermal sensitizer applicable to tumor ablation

Herein, we report a pH stimulus-disaggregated BODIPY sensitizer (PTS) with low background-toxicity for achieving activated photodynamic/photothermal tumor therapy. Both the photodynamic and photothermal properties of PTS can be activated under acidic conditions, and PTS exhibits excellent antitumor...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (13), p.1956-1959
Main Authors: Liu, Yongchao, Xu, Chengyan, Teng, Lili, Liu, Hong-Wen, Ren, Tian-Bing, Xu, Shuai, Lou, Xiaofeng, Guo, Haowei, Yuan, Lin, Zhang, Xiao-Bing
Format: Article
Language:English
Subjects:
Ablation
Animals
Anticancer properties
Biocompatibility
Biomedical materials
Boron Compounds - chemistry
Boron Compounds - pharmacology
Boron Compounds - therapeutic use
Cell Line, Tumor
Cell Survival - drug effects
Humans
Hydrogen-Ion Concentration
In vivo methods and tests
Light
Mice
Mice, Inbred BALB C
Neoplasms - drug therapy
Photochemotherapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Photosensitizing Agents - therapeutic use
Phototherapy
Toxicity
Transplantation, Heterologous
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Summary:Herein, we report a pH stimulus-disaggregated BODIPY sensitizer (PTS) with low background-toxicity for achieving activated photodynamic/photothermal tumor therapy. Both the photodynamic and photothermal properties of PTS can be activated under acidic conditions, and PTS exhibits excellent antitumor properties, which is revealed by both in vitro and in vivo tests. A pH activated photodynamic/photothermal sensitizer applicable to tumor ablation.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09790b