Fsp-rich and diverse fragments inspired by natural products as a collection to enhance fragment-based drug discovery

Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to generate novel, three-dimensional fragments which ea...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2020-02, Vol.56 (15), p.228-2283
Main Authors: Hanby, Abigail R, Troelsen, Nikolaj S, Osberger, Thomas J, Kidd, Sarah L, Mortensen, Kim T, Spring, David R
Format: Article
Language:English
Online Access:Get full text
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Summary:Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening. Utilising an efficient strategy, two key building block diastereomers were harnessed to generate novel, three-dimensional fragments which each possess numerous synthetically accessible fragment growth positions. Herein, we describe the natural product inspired synthesis of 38 complex small molecules based upon 20 unique frameworks suitable for fragment-based screening.
ISSN:1359-7345
1364-548X
DOI:10.1039/c9cc09796a