Enhancing P NMR relaxation rates with a kinetically inert gadolinium complex

• Published in: Dalton transactions : an international journal of inorganic chemistry 2020-03, Vol.49 (9), p.2989-2993
• Main Authors: Tear, Louise R, Maguire, Mahon L, Tropiano, Manuel, Yao, Kezi, Farrer, Nicola J, Faulkner, Stephen, Schneider, Jurgen E
• Format: Article
• Language: English
• ISSN: 1477-9226; 1477-9234
• DOI: 10.1039/c9dt03761f

The kinetically stable heptadentate gadolinium complex Gd.pDO3A ( 1.Gd ) demonstrates significant 31 P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate. Gd.pDO3A ( 1.Gd ) binds these species in fast exchange, enabling the relaxation of the bulk phosphate species in solution. This gives rise to 31 P relaxation enhancements up to 250-fold higher than those observed for 31 P relaxation enhancements with the commercial MRI contrast agent Gd.DOTA (DOTAREM), 2 . Gd.pDO3A-like complexes may have potential applications as 31 P magnetic resonance contrast agents, since shortening the T 1 relaxation time of phosphate species would reduce the time needed to acquire 31 P-MR spectra. The heptadentate gadolinium complex Gd.pDO3A ( 1.Gd ) generates significant 31 P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate.