A cytochrome c-urea functionalized dipeptide conjugate: an efficient HBD framework to synthesize 4-pyrans one-pot multicomponent reaction

• Published in: Green chemistry : an international journal and green chemistry resource : GC 2020-02, Vol.22 (3), p.956-968
• Main Authors: Saini, Sanjeev, Mayank, Kaur, Navneet, Singh, Narinder
• Format: Article
• ISSN: 1463-9262; 1463-9270
• DOI: 10.1039/c9gc03512e

This work is focused on the development of an efficient and green protocol for the one-pot multicomponent synthesis of a series of 4 H -pyran derivatives. Herein, a proteinpeptide conjugate (SS1Cyt. c) is synthesized and characterized using Circular Dichroism (CD), UV-Visible absorption spectroscopy, and docking studies. The whole assembly is used as an efficient catalytic system by incorporating a derivatized dipeptide molecule in the hydrophobic cavities of the protein Cytochrome c (Cyt. c) that leads to the activation of Hydrogen Bond Donating (HBD) units of a urea derivative of a dipeptide ( SS1 ). The HBD units tend to show non-covalent interactions with the reactant species responsible for triggering the occurrence of an organic transformation. Also, the stability and binding interactions of SS1Cyt. c with the multicomponent reactants involved in the organic transformation are studied in detail using MD-simulation studies. It is a metal-free catalyst and provides higher yield in relatively short reaction times. As per green chemistry principles, the catalyst has provided us ideal Eco-scale and E factor scores of 79 and 0.089, respectively. This work is focused on the development of an efficient and green protocol for the one-pot multicomponent synthesis of a series of 4 H -pyran derivatives.