Origami-paper-based device for microvesicle/exosome preconcentration and isolation

Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables t...

Full description

Saved in:
Bibliographic Details
Published in:Lab on a chip 2019-11, Vol.19 (23), p.3917-3921
Main Authors: Kim, Hyerin, Lee, Kyu Hyoung, Han, Sung Il, Lee, Dongho, Chung, Seok, Lee, Dohwan, Lee, Jeong Hoon
Format: Article
Language:English
Subjects:
Biomarkers
Damage
Ion concentration
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Microvesicles and exosomes are promising liquid biopsy biomarkers. However, conventional isolation techniques damage and contaminate the biomarkers. We developed an origami-paper-based device for effective isolation of biomarkers with less damage and in fewer steps. The multi-folded device enables the preconcentration of the microvesicles/exosomes on specific layers (∼5-fold) by the ion concentration polarization technique and they were simply isolated from the rest of the sample by unfolding the device. An origami-paper-based device was developed for effective preconcentration and isolation of microvesicles/exosomes by ion concentration polarization.
ISSN:1473-0197
1473-0189
DOI:10.1039/c9lc00796b