The properties of the sonochemically functionalized nonsteroidal anti-inflammatory drug ketorolac in an FeO-graphene oxide nanocomposite

Metallodrugs are in clinical use for the treatment of some diseases. A feasible sonochemical method is described for the complexation of the nonsteroidal anti-inflammatory drug, ketorolac, with an Fe 3 O 4 -graphene oxide nanocomposite. The extraction of ketorolac from this nanocomposite was studied...

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Bibliographic Details
Published in:New journal of chemistry 2019-10, Vol.43 (41), p.16118-16122
Main Authors: Fiadosenka, Uladzimir, Matsukovich, Anna, Tabulina, Ljudmila, Labunov, Vladimir, Radziuk, Darya
Format: Article
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Summary:Metallodrugs are in clinical use for the treatment of some diseases. A feasible sonochemical method is described for the complexation of the nonsteroidal anti-inflammatory drug, ketorolac, with an Fe 3 O 4 -graphene oxide nanocomposite. The extraction of ketorolac from this nanocomposite was studied in aqueous solutions at pH = 1, 5 and 8, imitating the gastrointestinal medium. A feasible sonochemical method is developed for the complexation of nonsteroidal anti-inflammatory drug ketorolac with the Fe 3 O 4 -graphene oxide nanocomposite.
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj03730f