Advanced lithium substituted hydroxyapatite nanoparticles for antimicrobial and hemolytic studies

In this study, pure hydroxyapatite (HAP) and lithium substituted hydroxyapatite (Li-HAP) nanoparticles were synthesized by a sonochemical synthesis process and investigated for their antimicrobial and hemolytic activities. The synthesized HAP and Li-HAP were characterized by X-ray diffraction (XRD),...

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Bibliographic Details
Published in:New journal of chemistry 2019-12, Vol.43 (47), p.18484-18494
Main Authors: Padmanabhan, Varun Prasath, , Sagadevan, Suresh, Hoque, Md Enamul, Kulandaivelu, Ravichandran
Format: Article
Language:English
Subjects:
Antiinfectives and antibacterials
Biocompatibility
Biological effects
Crystallites
Electron microscopy
Fourier transforms
Functional groups
Human performance
Hydroxyapatite
Infrared analysis
Infrared spectroscopy
Lithium
Microscopy
Morphology
Nanoparticles
Substitutes
Synthesis
Toxicity
X-ray diffraction
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Summary:In this study, pure hydroxyapatite (HAP) and lithium substituted hydroxyapatite (Li-HAP) nanoparticles were synthesized by a sonochemical synthesis process and investigated for their antimicrobial and hemolytic activities. The synthesized HAP and Li-HAP were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectroscopy. The XRD analysis confirmed the formation of the HAP phase both in the synthesized pure HAP and Li-HAP samples. It was also observed that the crystallite size was decreased in Li-HAP compared to pure HAP. FTIR analysis confirmed the presence of various functional groups ( e.g. hydroxyl, phosphate etc. groups). Generally, hydroxyapatite has a rod and plate-like morphology. Upon doping, the rod and plate-like morphologies were modified to agglomerated needle-shaped HAP crystals. Antimicrobial, hemolytic and MTT studies were performed using human pathogens, human blood, and human bone cells, respectively, to investigate the biological activities of the synthesized HAP samples. The biological test results evidenced the biocompatibility and cytotoxicity of the HAP samples with better functionality of Li-HAP. In this study, pure hydroxyapatite (HAP) and lithium substituted hydroxyapatite (Li-HAP) nanoparticles were synthesized by a sonochemical synthesis process and investigated for their antimicrobial and hemolytic activities.
ISSN:1144-0546
1369-9261
DOI:10.1039/c9nj03735g