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Rhodium()-catalyzed vinylation/[2 + 1] carbocyclization of 1,6-enynes with α-diazocarbonyl compounds

A sequential Rh( i )-catalyzed vinylation/[2 + 1]carbocyclization between enynes and diazo compounds has been developed. This transformation features a wide range of enynes and acceptor/acceptor diazo compounds, providing easy access to versatile vinyl-substituted azabicyclo[3.1.0]hexanes having a b...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2019-07, Vol.17 (29), p.742-754
Main Authors: Huang, Junmin, Hu, Xinwei, Chen, Fengjuan, Gui, Jiao, Zeng, Wei
Format: Article
Language:English
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Summary:A sequential Rh( i )-catalyzed vinylation/[2 + 1]carbocyclization between enynes and diazo compounds has been developed. This transformation features a wide range of enynes and acceptor/acceptor diazo compounds, providing easy access to versatile vinyl-substituted azabicyclo[3.1.0]hexanes having a broad tolerance to functional groups. Rh( i )-catalyzed coupling-cyclization of enynes with diazo compounds has been developed to obtain versatile vinyl-substituted azabicyclo[3.1.0]hexanes.
ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob01028a