Doxorubicin loaded ferritin nanoparticles for ferroptosis enhanced targeted killing of cancer cells

In recent years, ferroptosis has been investigated widely as a new form of cell death. Development of nanodrugs for ferroptosis induction in cancer cells may be a promising approach for cancer treatment. Here, we developed a type of nanoparticle consisting of the antitumor drug doxorubicin and exoge...

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Bibliographic Details
Published in:RSC advances 2019-09, Vol.9 (49), p.28548-28553
Main Authors: Yang, Runlin, Li, Yaoqi, Wang, Xinyu, Yan, Junjie, Pan, Donghui, Xu, Yuping, Wang, Lizhen, Yang, Min
Format: Article
Language:English
Subjects:
Cancer
Cell death
Chemistry
Doxorubicin
Ferritin
Nanoparticles
Toxicity
Transferrin
Tumors
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Summary:In recent years, ferroptosis has been investigated widely as a new form of cell death. Development of nanodrugs for ferroptosis induction in cancer cells may be a promising approach for cancer treatment. Here, we developed a type of nanoparticle consisting of the antitumor drug doxorubicin and exogenous ferritin. The drug loading process did not change the size of ferritin obviously. And this nanoparticle could induce the accumulation of ROS and cell ferroptosis for transferrin receptor overexpressed tumor cell, HT29. The ferroptosis process was also confirmed using inhibitors for ferroptosis. The cytotoxicity of this nanoparticle is similar to that of free DOX. This study provides a new strategy for targeting and killing transferrin receptor overexpressed tumor cells. DOX loaded ferritin selectively induces ferroptosis enhanced killing of transferrin receptor 1 overexpressed cancer cells.
ISSN:2046-2069
2046-2069
DOI:10.1039/c9ra04478g