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study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study

Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the...

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Published in:RSC advances 2019-10, Vol.9 (53), p.3178-3191
Main Authors: Gull, Nafisa, Khan, Shahzad Maqsood, Zahid Butt, Muhammad Taqi, Khalid, Syed, Shafiq, Muhammad, Islam, Atif, Asim, Sumreen, Hafeez, Sadaf, Khan, Rafi Ullah
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container_end_page 3191
container_issue 53
container_start_page 3178
container_title RSC advances
container_volume 9
creator Gull, Nafisa
Khan, Shahzad Maqsood
Zahid Butt, Muhammad Taqi
Khalid, Syed
Shafiq, Muhammad
Islam, Atif
Asim, Sumreen
Hafeez, Sadaf
Khan, Rafi Ullah
description Systematic administration of painkillers and anti-inflammatory drugs is routinely employed to minimize pain and bodily disorders. Controlled drug delivery has the potential to improve the outcomes of disorders by providing sustained exposure to efficacious drug concentrations. Herein, we report the fabrication of multi-responsive hydrogels using reactive and functional polymers such as chitosan and polyvinyl pyrrolidone by varying the concentration of a cleavable crosslinker, tetraethyl orthosilicate. The swelling indices of the hydrogels were evaluated in distilled water, solutions with different pH values and different electrolytes. FTIR, WAXRD and TGA were conducted to investigate the structures, crystallinities and thermal stabilities of the prepared multi-responsive hydrogels, respectively. The ultimate tensile strength and elongations at break of the fabricated hydrogels were investigated to assess their mechanical stability. Optical microscopy, biodegradation, antimicrobial and cytotoxicity analyses were further carried out to verify the magnified crosslinked and porous structures, biodegradabilities, biocompatibilities and toxic behaviour of the as-prepared hydrogels, respectively. Drug release analysis was conducted to evaluate their release behaviour in PBS, SGF, SIF and electrolyte solutions. The overall results indicate the successful development of novel, non-toxic and sustained drug deliverable hydrogels, which can be considered as a paramount success towards the fabrication of controlled drug delivery systems. Pictorial diagram of multi-responsive hydrogels for controlled drug release system.
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title study of chitosan-based multi-responsive hydrogels as drug release vehicles: a preclinical study
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