Detecting lysozyme unfolding the fluorescence of lysozyme encapsulated gold nanoclusters

Protein misfolding plays a critical role in the manifestation of amyloidosis type diseases. Therefore, understanding protein unfolding and the ability to track protein unfolding in a dynamic manner are of considerable interest. Fluorescence-based techniques are powerful tools for gaining real-time i...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2019-02, Vol.7 (7), p.1167-1175
Main Authors: Alkudaisi, Nora, Russell, Ben A, Jachimska, Barbara, Birch, David J. S, Chen, Yu
Format: Article
Language:English
Online Access:Get full text
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Summary:Protein misfolding plays a critical role in the manifestation of amyloidosis type diseases. Therefore, understanding protein unfolding and the ability to track protein unfolding in a dynamic manner are of considerable interest. Fluorescence-based techniques are powerful tools for gaining real-time information about the local environmental conditions of a probe on the nanoscale. Fluorescent gold nanoclusters (AuNCs) are a new type of fluorescent probes which are
ISSN:2050-750X
2050-7518
DOI:10.1039/c9tb00009g