Affinity of plant viral nanoparticle potato virus X (PVX) towards malignant B cells enables cancer drug delivery

Non-Hodgkin's B cell lymphomas (NHL) include a diverse set of neoplasms that constitute ∼90% of all lymphomas and the largest subset of blood cancers. While chemotherapy is the first line of treatment, the efficacy of contemporary chemotherapies is hampered by dose-limiting toxicities. Partly d...

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Bibliographic Details
Published in:Biomaterials science 2020-07, Vol.8 (14), p.3935-3943
Main Authors: Shukla, Sourabh, Roe, Anne Jessica, Liu, Ruifu, Veliz, Frank A, Commandeur, Ulrich, Wald, David N, Steinmetz, Nicole F
Format: Article
Language:English
Subjects:
Affinity
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
B-Lymphocytes
Cancer
Chemotherapy
Drug Delivery Systems
Humans
Lymphoma
Nanoparticles
Neoplasms
Neoplasms - drug therapy
Potatoes
Potexvirus
Survival
Viruses
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Summary:Non-Hodgkin's B cell lymphomas (NHL) include a diverse set of neoplasms that constitute ∼90% of all lymphomas and the largest subset of blood cancers. While chemotherapy is the first line of treatment, the efficacy of contemporary chemotherapies is hampered by dose-limiting toxicities. Partly due to suboptimal dosing, ∼40% of patients exhibit relapsed or refractory disease. Therefore more efficacious drug delivery systems are urgently needed to improve survival of NHL patients. In this study we demonstrate a new drug delivery platform for NHL based on the plant virus Potato virus X (PVX). We observed a binding affinity of PVX towards malignant B cells. In a metastatic mouse model of NHL, we show that systemically administered PVX home to tissues harboring malignant B cells. When loaded with the chemotherapy monomethyl auristatin (MMAE), the PVX nanocarrier enables effective delivery of MMAE to human B lymphoma cells in a NHL mouse model leading to inhibition of lymphoma growth in vivo and improved survival. Thus, PVX nanoparticle is a promising drug delivery platform for B cell malignancies. Plant vital nanoparticle PVX shows a binding affinity towards malignant B cells and traffics to metastatic lymphoma sites in mice challenged with B cell lymphoma, thus enabling NHL-specific drug delivery.
ISSN:2047-4830
2047-4849
DOI:10.1039/d0bm00683a